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In vivo imaging of estrogen receptor concentration in the endometrium and myometrium using FES PET--influence of menstrual cycle and endogenous estrogen level.
http://hdl.handle.net/10098/1440
http://hdl.handle.net/10098/1440012a89ff-89d4-477f-a738-30e114dc575f
名前 / ファイル | ライセンス | アクション |
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tsuchida_invivo.pdf (124.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-01-18 | |||||
タイトル | ||||||
タイトル | In vivo imaging of estrogen receptor concentration in the endometrium and myometrium using FES PET--influence of menstrual cycle and endogenous estrogen level. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Estrogen receptor concentration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 16α-[18F]fluoro-17β-estradiol (FES) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Positron emission tomography (PET) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Menstrual cycle | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Endogenous estrogen level | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
TSUCHIDA, Tatsuro
× TSUCHIDA, Tatsuro× OKAZAWA, Hidehiko× MORI, Tetsuya× KOBAYASHI, Masato× YOSHIDA, Yoshio× FUJIBAYASHI, Yasuhisa× ITOH, Harumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose The goals of this study were to measure estrogen receptor (ER) concentration in the endometrium and myometrium using 16α-[18F]fluoro-17β-estradiol (FES) positron emission tomography (PET) and to investigate the relationship between changes in these parameters with the menstrual cycle and endogenous estrogen levels. Methods Sixteen female healthy volunteers were included in this study. After blood sampling to measure endogenous estrogen level, FES PET image was acquired 60 min postinjection of FES. After whole-body imaging of FES PET, averaged standardized uptake values (SUVs) in the endometrium and myometrium were measured, and the relationship between FES uptake and menstrual cycle or endogenous estrogen level was evaluated. Results Endometrial SUV was significantly higher in the proliferative phase than in the secretory phase (6.03±1.05 vs. 3.97±1.29, P=.022). In contrast, there was no significant difference in myometrial SUV when the proliferative and secretory phases were compared (P=.23). Further, there was no correlation between SUV and endogenous estrogen level in the proliferative phase. Conclusions The change of ER concentration relative to menstrual cycle as characterized by FES PET was consistent with those from previous reports that used an immunohistochemical technique. These data suggest that FES PET is a feasible, noninvasive method for characterizing changes in ER concentration. | |||||
書誌情報 |
Nuclear medicine and biology 巻 34, 号 2, p. 205-210, 発行日 2007-02 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 9698051 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00006282 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.nucmedbio.2006.12.003 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |