| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-02-12 |
| タイトル |
|
|
タイトル |
Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
fluorodeoxyglucose 18F |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
idiopathic pulmonary fibrosis |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
positron emission tomography |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
survival analysis |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 著者 |
Umeda, Yukihiro
Demura, Yoshiki
Morikawa, Miwa
Anzai, Masaki
Kadowaki, Maiko
Ameshima, Shingo
Tsuchida, Tatsuro
Tsujikawa, Tetsuya
Kiyono, Yasushi
Okazawa, Hidehiko
Ishizaki, Takeshi
Ishizuka, Tamotsu
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
The aim of this prospective study was to clarify whether dual-time-point (18)F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. METHODS: Fifty IPF patients underwent (18)F-FDG PET examinations at 2 time points: 60 min (early imaging) and 180 min (delayed imaging) after (18)F-FDG injection. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival. RESULTS: A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality (hazard ratio, 7.31; 95% confidence interval, 2.64-20.3; P = 0.0001). CONCLUSION: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF. |
| 書誌情報 |
Jounal of Nuclear Medicine
巻 56,
号 12,
p. 1869-1875,
発行日 2015-12
|
| 出版者 |
|
|
出版者 |
Society of Nuclear Medicine |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1615505 |
| 書誌レコードID |
|
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|
識別子タイプ |
NCID |
|
|
関連識別子 |
TD00006180 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.2967/jnumed.115.163360 |
| 著者版フラグ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
10098-9769.pdf (1.4 MB)
