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Pharmacoethnicity of docetaxel-induced severe neutropenia: integrated analysis of published phase II and III trials
http://hdl.handle.net/10098/4847
http://hdl.handle.net/10098/4847d315c3a8-386a-4629-b0b1-e98c1b1ea677
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
IJCO2011.pdf (251.7 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2012-01-19 | |||||
| タイトル | ||||||
| タイトル | Pharmacoethnicity of docetaxel-induced severe neutropenia: integrated analysis of published phase II and III trials | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Ethnic differences | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Docetaxel | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Logistic regression | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Neutropenia | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| 著者 |
YANO, Ryoichi
× YANO, Ryoichi× KONNO, Aya× WATANABE, Kyohei× TSUKAMOTO, Hitoshi× KAYANO, Yuichiro× OHNAKA, Hiroaki× GOTO, Nobuyuki× NAKAMURA, Toshiaki× MASADA, Mikio |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background Ethnic differences in drug susceptibility and toxicity are a major concern, not only in drug development but also in the clinical setting. We review the toxicity profiles of docetaxel according to dose and ethnicity. Methods We analyzed phase II and III clinical trials that included a once-every-3-weeks single-agent docetaxel arm. Logistic regression analysis was applied to identify the significant variables affecting the reported incidence of docetaxel-induced severe neutropenia. Results Multivariate logistic regression analysis identified studies conducted in Asia [odds ratio (OR) 19.0; 95% confidence interval (95% CI) 3.64–99.0] and docetaxel dose (OR 1.08; 95% CI 1.03–1.13) as independent variables for the incidence of grade 3/4 neutropenia. Conclusions There is a significant difference in the incidence of docetaxel-induced severe neutropenia between Asian and non-Asian clinical studies. Physicians and pharmacists should consider ethnic diversity in docetaxel toxicity when interpreting the results of clinical trials. | |||||
| 書誌情報 |
International Journal of Clinical Oncology 巻 16, 号 6, 発行日 2011-11 |
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| 出版者 | ||||||
| 出版者 | 日本癌治療学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 13419625 | |||||
| 書誌レコードID | ||||||
| 識別子タイプ | NCID | |||||
| 関連識別子 | TD00006168 | |||||
