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Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis
http://hdl.handle.net/10098/9769
http://hdl.handle.net/10098/9769f71f2014-4c61-4a50-a1a7-000cea272cee
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
10098-9769.pdf (1.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2016-02-12 | |||||
| タイトル | ||||||
| タイトル | Prognostic Value of Dual-Time-Point 18F-FDG PET for Idiopathic Pulmonary Fibrosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | fluorodeoxyglucose 18F | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | idiopathic pulmonary fibrosis | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | positron emission tomography | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | survival analysis | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| 著者 |
Umeda, Yukihiro
× Umeda, Yukihiro× Demura, Yoshiki× Morikawa, Miwa× Anzai, Masaki× Kadowaki, Maiko× Ameshima, Shingo× Tsuchida, Tatsuro× Tsujikawa, Tetsuya× Kiyono, Yasushi× Okazawa, Hidehiko× Ishizaki, Takeshi× Ishizuka, Tamotsu |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The aim of this prospective study was to clarify whether dual-time-point (18)F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. METHODS: Fifty IPF patients underwent (18)F-FDG PET examinations at 2 time points: 60 min (early imaging) and 180 min (delayed imaging) after (18)F-FDG injection. The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival. RESULTS: A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). In addition, a univariate Cox model showed that positive RI-SUV as a binary variable was a significant indicator of mortality (hazard ratio, 7.31; 95% confidence interval, 2.64-20.3; P = 0.0001). CONCLUSION: Our results demonstrate that positive RI-SUV is strongly predictive of earlier deterioration of pulmonary function and higher mortality in patients with IPF. | |||||
| 書誌情報 |
Jounal of Nuclear Medicine 巻 56, 号 12, p. 1869-1875, 発行日 2015-12 |
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| 出版者 | ||||||
| 出版者 | Society of Nuclear Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1615505 | |||||
| 書誌レコードID | ||||||
| 識別子タイプ | NCID | |||||
| 関連識別子 | TD00006180 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2967/jnumed.115.163360 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AO | |||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||
