@article{oai:u-fukui.repo.nii.ac.jp:00028275,
 author = {上林, 大岳 and 西島, 浩二 and 打波, 郁子 and 山本, 真 and 佐藤, 久美子 and 高橋, 仁 and 折坂, 誠 and 黒川, 哲司 and 吉田, 好雄 and KAMIBAYASHI, Daigaku and NISHIJIMA, Koji and UCHINAMI, Ikuko and YAMAMOTO, Makoto and SATO, Kumiko and TAKAHASHI, Jin and ORISAKA, Makoto and KUROKAWA, Tetsuji and YOSHIDA, Yoshio},
 issue = {1},
 journal = {福井大学医学部研究雑誌},
 month = {Jan},
 note = {Although antihypertensive therapy is recommended for management of hypertension in pregnant women, the criteria for initiation and maintenance of treatment have not been established. We report a case involving a 38-year-old pregnant woman with severe hypertension and proteinuria who was referred to our facility at 23 weeks 0 days of gestation. Ultrasonographic monitoring of fetal well-being showed that fluctuations in the maternal blood pressure (BP) were rapidly reflected by the results of fetal umbilical artery Doppler velocimetry, e.g., the fetal diastolic umbilical artery flow normalized when the patient's BP decreased to 150/88 mmHg, but disappeared when the BP further decreased to 120/80 mmHg. Thus, the patient's hydralazine dose was adjusted according to fetal ultrasound findings. When the patient subsequently showed no response to hydralazine administration, which was reflected by the persistent absence of the diastolic component of umbilical artery flow in Doppler velocimetry, emergency Caesarean section was performed at 23 weeks 6 days of gestation, and both the mother and infant showed good clinical outcomes. Our case thus highlights the value of Doppler velocimetry in monitoring patient responsiveness to antihypertensive therapy.},
 pages = {1--4},
 title = {重症妊娠高血圧腎症における新たな降圧指針作成の可能性 : 胎児臍帯動脈血流速度波形からのアプローチ},
 volume = {14},
 year = {2014}
}