{"created":"2023-05-15T10:27:39.532780+00:00","id":23154,"links":{},"metadata":{"_buckets":{"deposit":"640c7581-a2c4-4f8f-817d-a3dfa1647f55"},"_deposit":{"created_by":1,"id":"23154","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"23154"},"status":"published"},"_oai":{"id":"oai:u-fukui.repo.nii.ac.jp:00023154","sets":["2397:2398:2481:2821"]},"author_link":["67576","67577","67575"],"item_2_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"59","bibliographicPageStart":"58","bibliographic_titles":[{"bibliographic_title":"福井大学 重点研究成果集2009 ―明日への挑戦―"}]}]},"item_2_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"脂肪蓄積型心筋症は心筋細胞内に脂肪が蓄積して脂肪毒性から機能障害に至る心疾患 で、糖尿病や肥満症に合併する。脂肪滴関連蛋白:Adipose Differentiation-Related Protein (ADRP) は心筋にも発現するため、心筋特異的にADRP を過剰発現するトランスジェニッ ク (Tg) マウスを作製して解析した。野生型マウスに比して、 Tgマウスの心筋内には多数 のトリグリセリド(TAG)脂肪滴の蓄積を認め、脂肪蓄積型心筋症像を呈した。Tg マウスの 心筋ではTAG とコレステリルエステルを分解するホルモン感受性リパーゼ(HSL)活性が 50%低下しおり、心筋HSLの過剰発現はADRPによる脂肪蓄積を完全に抑制した。以上よ り心筋ADRPはHSL の機能を抑制して脂肪蓄積を誘導する可能性が示唆された。","subitem_description_type":"Abstract"}]},"item_2_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"競争的配分経費(医学部)","subitem_description_type":"Other"}]},"item_2_relation_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"TD00008023","subitem_relation_type_select":"NCID"}}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 仁弥"}],"nameIdentifiers":[{"nameIdentifier":"67575","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高橋, 貞夫"}],"nameIdentifiers":[{"nameIdentifier":"67576","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小泉, 勤"}],"nameIdentifiers":[{"nameIdentifier":"67577","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-04"}],"displaytype":"detail","filename":"BD00008023_001.pdf","filesize":[{"value":"491.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BD00008023_001.pdf","url":"https://u-fukui.repo.nii.ac.jp/record/23154/files/BD00008023_001.pdf"},"version_id":"7f7e2f95-e1e1-4c31-b8d5-6205f0df7f36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪毒性","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipolysis","subitem_subject_scheme":"Other"},{"subitem_subject":"遊離脂肪酸","subitem_subject_scheme":"Other"},{"subitem_subject":"エネルギー代謝","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪蓄積型心筋症における Adipose Differentiation-Related Protein (ADRP) の機能-II","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪蓄積型心筋症における Adipose Differentiation-Related Protein (ADRP) の機能-II"}]},"item_type_id":"2","owner":"1","path":["2821"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-28"},"publish_date":"2009-04-28","publish_status":"0","recid":"23154","relation_version_is_last":true,"title":["脂肪蓄積型心筋症における Adipose Differentiation-Related Protein (ADRP) の機能-II"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T11:40:05.108395+00:00"}