{"created":"2023-05-15T10:25:31.276877+00:00","id":20546,"links":{},"metadata":{"_buckets":{"deposit":"f30e4be2-09c9-40e6-9153-483dfb8d0942"},"_deposit":{"created_by":1,"id":"20546","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"20546"},"status":"published"},"_oai":{"id":"oai:u-fukui.repo.nii.ac.jp:00020546","sets":["2392:2393"]},"author_link":["59404","59400","59407","59410","59398","59406","59408","59403","59399","59405","59409","59401","59402","59411"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1600","bibliographicPageStart":"1597","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"日本病院薬剤師会雑誌"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年の文献報告では、バンコマイシン(以下、VCM)の有効性は24時間の血清中濃度時間曲線下面積(以下、AUC_24)と最小発育阻止濃度(以下、MIC)の比(以下、AUC_24/MIC)とよく相関し、methicillin-resitant Staphylococcus aureus(以下、MRSA)肺炎においてはその値が400以上必要と報告されている。我々は、現在のVCM治療域濃度の妥当性を評価するため、トラフ濃度とAUC_24との関係、さらにAUC_24/MICの要素であるMICについて調査した。 福井大学医学部附属病院においてVCMが投与された成人患者188名を対象とし、ベイジアン法を用いて求めた推定動態パラメータから定常状態におけるAUC_24を算出した。その結果、トラフ濃度と算出したAUC_24は、y=25.60x+124.39の回帰式で示された。得られた回帰式、並びにMRSA臨床分離株のMIC分布(MIC_50 1.5μg/mL, MIC_90 2μg/mL)から考えると、AUC_24/MIC>400を満たすためには、トラフ濃度を15～25μg/mL以上に保つ必要があると考えられた。","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本病院薬剤師会"}]},"item_10001_relation_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"TD00006296","subitem_relation_type_select":"NCID"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13418815","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塚本, 仁"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山下, 久美江"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢野, 良一"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中村, 敏明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"飛田, 征男"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山下, 政宣"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"政田, 幹夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TSUKAMOTO, Hitoshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMASHITA, Kumie","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YANO, Ryoichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAKAMURA, Toshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HIDA, Yukio","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YAMASHITA, Masanori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"MASADA, Mikio","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-04"}],"displaytype":"detail","filename":"BD00006296_001.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BD00006296_001.pdf","url":"https://u-fukui.repo.nii.ac.jp/record/20546/files/BD00006296_001.pdf"},"version_id":"a18782e6-0002-4e70-90ed-3994080a7f8b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バンコマイシン","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物血中濃度モニタリング(TDM)","subitem_subject_scheme":"Other"},{"subitem_subject":"ベイジアン法","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics/pharmacodynamics (PK/PD)","subitem_subject_scheme":"Other"},{"subitem_subject":"24時間の血清中濃度時間曲線下面積と最小発育阻止濃度の比(AUC_24/MIC)","subitem_subject_scheme":"Other"},{"subitem_subject":"Etest","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"PK/PDパラメータを指標としたバンコマイシンの薬物血中濃度モニタリング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"PK/PDパラメータを指標としたバンコマイシンの薬物血中濃度モニタリング"},{"subitem_title":"Monitoring of Serum Vancomycin Level Using PK/PD Parameters","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"1","path":["2393"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-03-04"},"publish_date":"2009-03-04","publish_status":"0","recid":"20546","relation_version_is_last":true,"title":["PK/PDパラメータを指標としたバンコマイシンの薬物血中濃度モニタリング"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T13:36:45.411351+00:00"}