@misc{oai:u-fukui.repo.nii.ac.jp:00020417, author = {松本, 英樹 and 加納, 永一 and Matsumoto, H and Kano, E}, month = {Jan}, note = {Nitric oxide and its metabolites such as peroxynitrite and nitric dioxide cause DNA damage and protein modifications.In addition,nitric oxide can induce p53 accumulation.As part of a feedback loop,p53 mediates transcriptional transrepression of inducible nitric oxide synthase.Recent studies have suggested the interactive effects of nitric oxide and p53 on cellular sensitivity against cancer therapeutic agents.This review summarizes current knowledge,including our findings,of the roles of nitric oxide in cellular response to cancer therapeutic agents,in particular radiation-induced bystander effect and the invoIvement of the p53 gene status in this regard.}, title = {NO ラジカルをイニシエーターとする放射線誘発バイスタンダー効果}, year = {2001} }