{"created":"2023-05-15T10:25:15.877150+00:00","id":20231,"links":{},"metadata":{"_buckets":{"deposit":"b55adae9-d313-4a7e-8d09-5858d9e4615c"},"_deposit":{"created_by":1,"id":"20231","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"20231"},"status":"published"},"_oai":{"id":"oai:u-fukui.repo.nii.ac.jp:00020231","sets":["2392:2393"]},"author_link":["58451","58450","58452","58453","58455","58449","58454"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"223","bibliographicPageStart":"217","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"HIGH ALTITUDE MEDICINE & BIOLOGY"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Kojonazarov, Baktybek, Jainagul Isakova, Baktybek Imanov, Nurmira Sovkhozova, Talantbek Sooronbaev, Takeshi Ishizaki, and Almaz A. Aldashev. Bosentan reduces pulmonary artery pressure in high altitude residents. High Alt Med Biol. 13:217  223, 2012.  Endothelin-1 (ET-1) plays a critical role in the regulation of pulmonary vascular tone. The aim of this study was to investigate the role of ET-1 in the pathogenesis of high altitude pulmonary arterial hypertension (HAPH). Methods: Pulmonary artery pressure (PAP) was measured by echocardiography in permanent residents of the Kyrgyz Republic (3200-4000m above sea level) both before and 3h after a single oral dose of ET receptor antagonist, bosentan (125mg). Plasma ET-1 levels were measured by ELISA assay. Genomic DNA was extracted from peripheral blood samples and the frequency of -3a and -4a alleles of the ET-1 gene determined by PCR. Results: Plasma ET-1 in HAPH highlanders was significantly higher than in healthy subjects (7.05±2.35 vs. 4.65±1.65pg/ml, p<0.002). After the treatment with 125mg bosentan, systolic PAP decreased from 46±1.9 to 37±2.2mm Hg ( p<0.01), and pulmonary artery acceleration time (PAAT) increased from 0.086±0.001 to 0.098±0.001 sec ( p<0.001). The frequency of the -4a allele was significantly higher in HAPH patients compared to healthy highlanders (0.43 vs. 0.3, X2=4.3, p=0.03). Conclusion: Increased ET-1 levels play an important role in development of HAPH.","subitem_description_type":"Abstract"}]},"item_10001_relation_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"TD00006202","subitem_relation_type_select":"NCID"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15270297","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kojonazarov, Baktybek"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Isakova, Jainagul"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Imanov, Bakytbek"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sovkhozova, Nurmira"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sooronbaev, Talantbek"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishizaki, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aldashev, Almaz A."}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-04"}],"displaytype":"detail","filename":"Bosentan_in_Highaltitude_Residents_2012.pdf","filesize":[{"value":"117.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Bosentan_in_Highaltitude_Residents_2012.pdf","url":"https://u-fukui.repo.nii.ac.jp/record/20231/files/Bosentan_in_Highaltitude_Residents_2012.pdf"},"version_id":"90f5935c-6985-4f7d-8756-caec6bf3c248"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"highlanders","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin-1","subitem_subject_scheme":"Other"},{"subitem_subject":"bosentan","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents"}]},"item_type_id":"10001","owner":"1","path":["2393"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-22"},"publish_date":"2013-08-22","publish_status":"0","recid":"20231","relation_version_is_last":true,"title":["Bosentan Reduces Pulmonary Artery Pressure in High Altitude Residents"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T13:42:50.505984+00:00"}