{"created":"2023-05-15T10:24:59.918171+00:00","id":19988,"links":{},"metadata":{"_buckets":{"deposit":"ac7844d2-c217-442f-a4db-aad94140f254"},"_deposit":{"created_by":1,"id":"19988","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"19988"},"status":"published"},"_oai":{"id":"oai:u-fukui.repo.nii.ac.jp:00019988","sets":["2392:2393"]},"author_link":["57588","57592","57587","57590","57591","57593","57589"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"7","bibliographicVolumeNumber":"823","bibliographic_titles":[{"bibliographic_title":"Journal of Chromatography B"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We developed a simple and sensitive stable-isotope dilution method for the quantification of 3-hydroxyglutaric acid (3HGA) and glutaric acid (GA) in body fluids. In our method, tert-butyldimethylsilyl (tBDMS) derivatives of 3HGA and GA were measured with a conventional electron-impact ionization (EI) mode in gas chromatography–mass spectrometry (GC–MS). The control values for 3HGA in nmol/ml were 0.15 ± 0.08 (serum; n = 10) and 0.07 ± 0.03 (CSF; n = 10). In addition, glutarylcarnitine and free carnitine were quantified by electrospray tandem mass spectrometry. Using these methods, we monitored 3HGA, GA, and glutarylcarnitine in the body fluids of three patients with glutaric aciduria type 1 found during newborn screening. None of the patients had experienced neurological strokes, which are possibly caused by the accumulation of 3HGA, at 15–24 months of age under a disease-specific treatment, including carnitine supplementation. Our data showed that 3HGA levels were relatively high in some serum samples with lower glutarylcarnitine and carnitine levels, suggesting that carnitine supplementation may play a role in preventing the accumulation of 3HGA in patients with this disease.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"TD00006126","subitem_relation_type_select":"NCID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jchromb.2005.03.031","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"15700232","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"SHIGEMATSU, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"HATA, Ikue"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TANAKA, Yukie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"TAJIMA, Go"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"SAKURA, Nobuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"NAITO, Etsuo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"YORIFUJI, Toru"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-04"}],"displaytype":"detail","filename":"Shigematsu_stab_2.pdf","filesize":[{"value":"218.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shigematsu_stab_2.pdf","url":"https://u-fukui.repo.nii.ac.jp/record/19988/files/Shigematsu_stab_2.pdf"},"version_id":"59355ebc-90fd-4a21-8a19-6adbb623f597"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glutaric acid","subitem_subject_scheme":"Other"},{"subitem_subject":"3-Hydroxyglutaric acid","subitem_subject_scheme":"Other"},{"subitem_subject":"Newborn screening","subitem_subject_scheme":"Other"},{"subitem_subject":"Carnitine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Stable-isotope dilution gas chromatography–mass spectrometric measurement of 3-hydroxyglutaric acid, glutaric acid and related metabolites in body fluids of patients with glutaric aciduria type 1 found in newborn screening","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stable-isotope dilution gas chromatography–mass spectrometric measurement of 3-hydroxyglutaric acid, glutaric acid and related metabolites in body fluids of patients with glutaric aciduria type 1 found in newborn screening"}]},"item_type_id":"10001","owner":"1","path":["2393"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-22"},"publish_date":"2007-11-22","publish_status":"0","recid":"19988","relation_version_is_last":true,"title":["Stable-isotope dilution gas chromatography–mass spectrometric measurement of 3-hydroxyglutaric acid, glutaric acid and related metabolites in body fluids of patients with glutaric aciduria type 1 found in newborn screening"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T13:46:51.433892+00:00"}