{"created":"2023-05-15T10:24:57.393076+00:00","id":19949,"links":{},"metadata":{"_buckets":{"deposit":"91df16ab-b1e7-4148-b62f-c158b4352148"},"_deposit":{"created_by":1,"id":"19949","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"19949"},"status":"published"},"_oai":{"id":"oai:u-fukui.repo.nii.ac.jp:00019949","sets":["2392:2393"]},"author_link":["57500","57501","57499"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-2","bibliographicPageEnd":"86","bibliographicPageStart":"82","bibliographicVolumeNumber":"386","bibliographic_titles":[{"bibliographic_title":"Clinica Chimica Acta"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Recent neonatal screening for isovaleric acidemia by tandem mass spectrometry based on dried blood spot levels of C5-acylcarnitines, including isovalerylcarnitine and its isomer, pivaloylcarnitine, which is derived from pivalate-generating antibiotics, has caused many false-positive results. We have developed a method to overcome this interference. Methods: The amounts of isovalerylglycine were determined by a stable-isotope dilution electrospray tandem mass spectrometric analysis, using multiple reaction monitoring with product ions of m/z 132, which were generated predominantly from quasi-molecular ions of isovalerylglycine butylester but apparently not from those of pivaloylglycine butylester. Results: Isovalerylglycine concentrations in dried blood spots of control newborns were 0.17 ± 0.03 nmol/ml, and those of patients with isovaleric acidemia ranged from 1.3 to 80.0 nmol/ml. Those of the newborns treated with antibiotics, which caused high C5-acylcarnitine levels (1.9 ± 1.7 nmol/ml) in dried blood spots, were 0.22 ± 0.05 nmol/ml. Conclusions: Our data showed that the present method is useful in eliminating the false-positive results due to antibiotics use in newborn screening for isovaleric acidemia.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_10001_relation_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"TD00006115","subitem_relation_type_select":"NCID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.cca.2007.08.003","subitem_relation_type_select":"DOI"}}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"98981","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_b1a7d7d4d402bcce","subitem_version_type":"AO"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shigematsu, Yosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikue, Hata"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Yukie"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-08-04"}],"displaytype":"detail","filename":"Shigemtsu_stab_1.pdf","filesize":[{"value":"456.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Shigemtsu_stab_1.pdf","url":"https://u-fukui.repo.nii.ac.jp/record/19949/files/Shigemtsu_stab_1.pdf"},"version_id":"5dc4da32-a593-4e0f-ae18-372099ae9403"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Isovalerylglycine","subitem_subject_scheme":"Other"},{"subitem_subject":"Isovalerylcarnitine","subitem_subject_scheme":"Other"},{"subitem_subject":"Pivaloylcarnitine","subitem_subject_scheme":"Other"},{"subitem_subject":"Isovaleric acidemia","subitem_subject_scheme":"Other"},{"subitem_subject":"Antibiotics","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"other","resourceuri":"http://purl.org/coar/resource_type/c_1843"}]},"item_title":"Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia"}]},"item_type_id":"10001","owner":"1","path":["2393"],"pubdate":{"attribute_name":"公開日","attribute_value":"2007-11-22"},"publish_date":"2007-11-22","publish_status":"0","recid":"19949","relation_version_is_last":true,"title":["Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-05-15T12:22:42.447805+00:00"}