@misc{oai:u-fukui.repo.nii.ac.jp:00019863,
 author = {MURAOKA, Noriaki and UEMATSU, Hidemasa and KIMURA, Hirohiko and IMAMURA, Yoshiaki and FUJIWARA, Yasuhiro and MURAKAMI, Makoto and YAMAGUCHI, Akio and ITOH, Harumi},
 month = {Jun},
 note = {Purpose: To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue. Materials and Methods: Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion-weighted (DW) echo-planar imaging (b value=0, 500 s/mm^2) was employed to calculate ADC. ADC values of cancer and non-cancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results. Results: Mean (±standard deviation) ADC value was significantly lower for tumor (1.27±0.52 ×10^<-3> mm^2/s) than for non-cancerous tissue (1.90±0.41×10^<-3> mm^2/s, P<0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis and mucin in each case. Regarding the density of fibrosis in cancer, 3 cases were classified to the loose fibrosis group, and the remaining 7 cases were classified to the dense fibrosis group. Mean ADC value was significantly higher in the loose fibrosis group (1.88±0.39×10^<-3> mm^2/s) than in the dense fibrosis group (1.01±0.29×10^<-3> mm^2/s, P<0.05). In quantitative analysis, ADC correlated well with proportion of collagenous fibers (r=-0.87, P<0.05). Conclusion: Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer.},
 title = {Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations},
 year = {2008}
}