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GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice
http://hdl.handle.net/10098/10852
http://hdl.handle.net/10098/108527efa8dc9-46af-42e3-895d-35afd7d402ed
名前 / ファイル | ライセンス | アクション |
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bd10121877.pdf (6.9 MB)
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This article is licensed under a Creative Commons Attribution 4.0 International License.
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2020-06-25 | |||||
タイトル | ||||||
タイトル | GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Medicine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Science | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
Murata, Koshi Murata
× Murata, Koshi Murata× Kinoshita, Tomoki× Fukazawa, Yugo× Kobayashi, Kenta× Kobayashi, Kazuto× Miyamichi, Kazunari× Okuno, Hiroyuki× Bito, Haruhiko× Sakurai, Yoshio× Yamaguchi, Masahiro× Mori, Kensaku× Manabe, Hiroyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Olfaction guides goal-directed behaviours including feeding. To investigate how central olfactory neural circuits control feeding behaviour in mice, we performed retrograde tracing from the lateral hypothalamus (LH), an important feeding centre. We observed a cluster of retrogradely labelled cells distributed in the posteroventral region of the olfactory peduncle. Histochemical analyses revealed that the majority of these retrogradely labelled projection neurons expressed glutamic acid decarboxylase 65/67 (GAD65/67), but not vesicular glutamate transporter 1 (VGluT1). We named this region containing GABAergic projection neurons the ventral olfactory nucleus (VON) to differentiate it from the conventional olfactory peduncle. VON neurons were less immunoreactive for DARPP-32, a striatal neuron marker, compared to neurons in the olfactory tubercle and nucleus accumbens, which distinguished the VON from the ventral striatum. Fluorescent labelling confirmed putative synaptic contacts between VON neurons and olfactory bulb projection neurons. Rabies-virus-mediated trans-synaptic labelling revealed that VON neurons received synaptic inputs from the olfactory bulb, other olfactory cortices, horizontal limb of the diagonal band, and prefrontal cortex. Collectively, these results identify novel GABAergic projection neurons in the olfactory cortex that may integrate olfactory sensory and top-down inputs and send inhibitory output to the LH, which may modulate odour-guided LH-related behaviours. | |||||
書誌情報 |
Scientific Reports 巻 9, p. 1-14, 発行日 2019-05-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20452322 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD10121877 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1038/s41598-019-43580-1 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |