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CD38, CD157, and RAGE as Molecular Determinants for Social Behavior
http://hdl.handle.net/10098/10836
http://hdl.handle.net/10098/1083630c4a2fb-5624-49d0-b996-020093329258
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
bd10121861.pdf (2.4 MB)
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Copyright of Cells (2073-4409) is the property of MDPI Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2020-02-28 | |||||
| タイトル | ||||||
| タイトル | CD38, CD157, and RAGE as Molecular Determinants for Social Behavior | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | ADVANCED glycation end-products | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | SINGLE nucleotide polymorphisms | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | AUTISM spectrum disorders | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PARKINSON'S disease | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | BLOOD-brain barrier | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | NERVOUS system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | cyclic adp-ribose (cadpr) | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | social memory | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | oxytocin transporter | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | QH301-705.5 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
| 資源タイプ | other | |||||
| 著者 |
Tanaka, Yukie
× Tanaka, Yukie× Higashida, Haruhiro× Hashii, Minako× Matsukawa, Shigeru× Higuchi, Yoshihiro× Gabata, Ryosuke× Tsubomoto, Makoto× Seishima, Noriko× Teramachi, Mitsuyo× Kamijima, Taiki× Hattori, Tsuyoshi× Hori, Osamu× Tsuji, Chiharu× Cherepanov, Stanislav M.× Shabalova, Anna A.× Gerasimenko, Maria× Minami, Kana× Yokoyama, Shigeru× Munesue, Sei-ichi× Harashima, Ai |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Recent studies provide evidence to support that cluster of differentiation 38 (CD38) and CD157 meaningfully act in the brain as neuroregulators. They primarily affect social behaviors. Social behaviors are impaired in Cd38 and Cd157 knockout mice. Single-nucleotide polymorphisms of the CD38 and CD157/BST1 genes are associated with multiple neurological and psychiatric conditions, including autism spectrum disorder, Parkinson's disease, and schizophrenia. In addition, both antigens are related to infectious and immunoregulational processes. The most important clues to demonstrate how these molecules play a role in the brain are oxytocin (OT) and the OT system. OT is axo-dendritically secreted into the brain from OT-containing neurons and causes activation of OT receptors mainly on hypothalamic neurons. Here, we overview the CD38/CD157-dependent OT release mechanism as the initiation step for social behavior. The receptor for advanced glycation end-products (RAGE) is a newly identified molecule as an OT binding protein and serves as a transporter of OT to the brain, crossing over the blood–brain barrier, resulting in the regulation of brain OT levels. We point out new roles of CD38 and CD157 during neuronal development and aging in relation to nicotinamide adenine dinucleotide+ levels in embryonic and adult nervous systems. Finally, we discuss how CD38, CD157, and RAGE are crucial for social recognition and behavior in daily life. [ABSTRACT FROM AUTHOR] | |||||
| 書誌情報 |
Cells 巻 9, 号 1, p. 62-1-16, 発行日 2019-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 20734409 | |||||
| 書誌レコードID | ||||||
| 識別子タイプ | NCID | |||||
| 関連識別子 | TD10121861 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/cells9010062 | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AO | |||||
| 出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce | |||||
