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Tissue Gene Expression of Renin-Angiotensin System in Human Type 2 Diabetic Nephropathy
http://hdl.handle.net/10098/1815
http://hdl.handle.net/10098/181595313c38-ca35-417d-80bc-77286cf448fe
名前 / ファイル | ライセンス | アクション |
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Tissue_gene_expression_of_renin-angiotensin_system.pdf (52.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-12-17 | |||||
タイトル | ||||||
タイトル | Tissue Gene Expression of Renin-Angiotensin System in Human Type 2 Diabetic Nephropathy | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
KONOSHITA, Tadashi
× KONOSHITA, Tadashi× WAKAHARA, Shigeyuki× MIZUNO, Shinichi× MOTOMURA, Makoto× AOYAMA, Chikako× MAKINO, Yasukazu× KAWAI, Yasuyuki× KATO, Norihiko× KONI, Ichiro× MIYAMORI, Isamu× MABUCHI, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | OBJECTIVE—Recent studies have proved that blockade of the renin-angiotensin system (RAS) retards the progression of diabetic nephropathy, whereas hyporeninemia is known as a typical state in diabetic subjects. The purpose of this study is to determine whether expression levels of RAS differ between nondiabetic and diabetic renal tissues with accurate quantitative method. RESEARCH DESIGN AND METHODS—Subjects were 66 nondiabetic and 8 diabetic patients with biopsy-proven renal diseases. The eight diabetic subjects suffered from type 2 diabetes with overt proteinuria. Renal histology revealed typical diffuse or nodular lesions with linear IgG deposit on immunofluorescent staining and thickened basement membrane on electronic microscopy. Total RNA from a small part of the renal cortical biopsy specimens was reverse-transcribed, and the resultant cDNA was amplified for new major components of RAS (i.e., renin, renin receptor, angiotensinogen, ACE, ACE2, angiotensin II type 1 receptor, and angiotensin II type 2 receptor) and measured. RESULTS—Among these components, a significant upregulation was observed in the ACE gene in diabetic renal tissue. CONCLUSIONS—The results suggest that renal tissue RAS might be activated in the respect that ACE gene expression is upregulated in spite of a tendency to low renin expression in type 2 diabetic nephropathy. | |||||
書誌情報 |
Diabetes care 巻 29, 号 4, p. 848-852, 発行日 2006-04 |
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出版者 | ||||||
出版者 | American Diabetes Association | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1495992 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00006322 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2337/diacare.29.04.06.dc05-1873 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |