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  1. B.医学系部門（医学部）
  2. 10. 学術雑誌掲載論文

Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association

http://hdl.handle.net/10098/9956
http://hdl.handle.net/10098/9956
2d20a4f4-d1df-42a3-ac29-3382a021b6c4
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2504685.pdf 2504685.pdf (1.1 MB)
〓 2016 Shimada et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Item type 学術雑誌論文 / Journal Article(1)
公開日 2016-05-18
タイトル
タイトル Serum CETP status is independently associated with reduction rates in LDL-C in pitavastatin-treated diabetic patients and possible involvement of LXR in its association
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_1843
資源タイプ other
著者 Shimada, Akihiro

× Shimada, Akihiro

Shimada, Akihiro
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Kimura, Hideki

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Kimura, Hideki
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Oida, Koji

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Oida, Koji
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Kanehara, Hideo

× Kanehara, Hideo

Kanehara, Hideo
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Bando, Yukihiro

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Bando, Yukihiro
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Sakamoto, Shinobu

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Sakamoto, Shinobu
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Wakasugi, Takanobu

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Wakasugi, Takanobu
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Saga, Takashi

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Saga, Takashi
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Ito, Yasuki

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Ito, Yasuki
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Kamiyama, Kazuko

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Kamiyama, Kazuko
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Mikami, Daisuke

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Mikami, Daisuke
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Iwano, Masayuki

× Iwano, Masayuki

Iwano, Masayuki
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Hirano, Tsutomu

× Hirano, Tsutomu

Hirano, Tsutomu
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Yoshida, Haruyoshi

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Yoshida, Haruyoshi
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抄録
内容記述タイプ Abstract
内容記述 Background: Statins decrease cholesteryl ester transfer protein (CETP) levels, which have been positively associated with hepatic lipid content as well as serum low density lipoproteins-cholesterol (LDL-C) levels. However, the relationship between the CETP status and statin-induced reductions in LDL-C levels has not yet been elucidated in detail. We herein examined the influence of the CETP status on the lipid-reducing effects of pitavastatin in hypercholesterolemic patients with type 2 diabetes mellitus as well as the molecular mechanism underlying pitavastatin-induced modifications in CETP levels. Methods: Fifty-three patients were treated with 2 mg of pitavastatin for 3 months. Serum levels of LDL-C, small dense (sd) LDL-C, and CETP were measured before and after the pitavastatin treatment. The effects of pitavastatin, T0901317, a specific agonist for liver X receptor (LXR) that reflects hepatic cholesterol contents, and LXR silencing on CETP mRNA expression in HepG2 cells were also examined by a real-time PCR assay. Results: The pitavastatin treatment decreased LDL-C, sdLDL-C, and CETP levels by 39, 42, and 23 %, respectively. Despite the absence of a significant association between CETP and LDL-C levels at baseline, baseline CETP levels and its percentage change were an independent positive determinant for the changes observed in LDL-C and sdLDL-C levels. The LXR activation with T0901317 (0.5 μM), an in vitro condition analogous to hepatic cholesterol accumulation, increased CETP mRNA levels in HepG2 cells by approximately 220 %, while LXR silencing markedly diminished the increased expression of CETP. Pitavastatin (5 μM) decreased basal CETP mRNA levels by 21 %, and this was completely reversed by T0901317. Conclusion: Baseline CETP levels may predict the lipid-reducing effects of pitavastatin. Pitavastatin-induced CETP reductions may be partially attributed to decreased LXR activity, predictable by the ensuing decline in hepatic cholesterol synthesis. Trial registration: UMIN Clinical Trials Registry ID UMIN000019020
書誌情報 Lipids in Health and Disease

巻 15, p. 57, 発行日 2016-05
出版者
出版者 BioMed Central
ISSN
収録物識別子タイプ ISSN
収録物識別子 1476511X
書誌レコードID
識別子タイプ NCID
関連識別子 TD00006197
DOI
関連タイプ isVersionOf
識別子タイプ DOI
関連識別子 10.1186/s12944-016-0223-6
著者版フラグ
出版タイプ AO
出版タイプResource http://purl.org/coar/version/c_b1a7d7d4d402bcce
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