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Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia
http://hdl.handle.net/10098/1181
http://hdl.handle.net/10098/1181e5758102-f68b-4021-b2d7-0e1212af2cbc
名前 / ファイル | ライセンス | アクション |
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Shigemtsu_stab_1.pdf (456.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-11-22 | |||||
タイトル | ||||||
タイトル | Stable-isotope dilution measurement of isovalerylglycine by tandem mass spectrometry in newborn screening for isovaleric acidemia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Isovalerylglycine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Isovalerylcarnitine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pivaloylcarnitine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Isovaleric acidemia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antibiotics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
Shigematsu, Yosuke
× Shigematsu, Yosuke× Ikue, Hata× Tanaka, Yukie |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Recent neonatal screening for isovaleric acidemia by tandem mass spectrometry based on dried blood spot levels of C5-acylcarnitines, including isovalerylcarnitine and its isomer, pivaloylcarnitine, which is derived from pivalate-generating antibiotics, has caused many false-positive results. We have developed a method to overcome this interference. Methods: The amounts of isovalerylglycine were determined by a stable-isotope dilution electrospray tandem mass spectrometric analysis, using multiple reaction monitoring with product ions of m/z 132, which were generated predominantly from quasi-molecular ions of isovalerylglycine butylester but apparently not from those of pivaloylglycine butylester. Results: Isovalerylglycine concentrations in dried blood spots of control newborns were 0.17 ± 0.03 nmol/ml, and those of patients with isovaleric acidemia ranged from 1.3 to 80.0 nmol/ml. Those of the newborns treated with antibiotics, which caused high C5-acylcarnitine levels (1.9 ± 1.7 nmol/ml) in dried blood spots, were 0.22 ± 0.05 nmol/ml. Conclusions: Our data showed that the present method is useful in eliminating the false-positive results due to antibiotics use in newborn screening for isovaleric acidemia. | |||||
書誌情報 |
Clinica Chimica Acta 巻 386, 号 1-2, p. 82-86, 発行日 2007-11 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 98981 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00006115 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.cca.2007.08.003 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |