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Materials and Methods: Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion-weighted (DW) echo-planar imaging (b value=0, 500 s/mm^2) was employed to calculate ADC. ADC values of cancer and non-cancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results. Results: Mean (±standard deviation) ADC value was significantly lower for tumor (1.27±0.52 ×10^\u003c-3\u003e mm^2/s) than for non-cancerous tissue (1.90±0.41×10^\u003c-3\u003e mm^2/s, P\u003c0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis and mucin in each case. Regarding the density of fibrosis in cancer, 3 cases were classified to the loose fibrosis group, and the remaining 7 cases were classified to the dense fibrosis group. Mean ADC value was significantly higher in the loose fibrosis group (1.88±0.39×10^\u003c-3\u003e mm^2/s) than in the dense fibrosis group (1.01±0.29×10^\u003c-3\u003e mm^2/s, P\u003c0.05). In quantitative analysis, ADC correlated well with proportion of collagenous fibers (r=-0.87, P\u003c0.05). Conclusion: Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "JOHN WILEY \u0026 SONS INC"}]}, "item_10001_relation_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "TD00006090", "subitem_relation_type_select": "NCID"}}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "10531807", "subitem_source_identifier_type": "ISSN"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "MURAOKA, Noriaki"}], "nameIdentifiers": [{"nameIdentifier": "57254", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "UEMATSU, Hidemasa"}], "nameIdentifiers": [{"nameIdentifier": "57255", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KIMURA, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "57256", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "IMAMURA, Yoshiaki"}], "nameIdentifiers": [{"nameIdentifier": "57257", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUJIWARA, Yasuhiro"}], "nameIdentifiers": [{"nameIdentifier": "57258", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "MURAKAMI, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "57259", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YAMAGUCHI, Akio"}], "nameIdentifiers": [{"nameIdentifier": "57260", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ITOH, Harumi"}], "nameIdentifiers": [{"nameIdentifier": "57261", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "clean_version_muraoka_JMRI.pdf", "filesize": [{"value": "790.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 790500.0, "url": {"label": "clean_version_muraoka_JMRI.pdf", "url": "https://u-fukui.repo.nii.ac.jp/record/19863/files/clean_version_muraoka_JMRI.pdf"}, "version_id": "aace1f63-6c35-4f8f-8d27-73562a21055e"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "pancreatic cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "diffusion-weighted imaging", "subitem_subject_scheme": "Other"}, {"subitem_subject": "apparent diffusion coefficient", "subitem_subject_scheme": "Other"}, {"subitem_subject": "histopathological correlations", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "other", "resourceuri": "http://purl.org/coar/resource_type/c_1843"}]}, "item_title": "Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations"}]}, "item_type_id": "10001", "owner": "1", "path": ["2393"], "permalink_uri": "http://hdl.handle.net/10098/2103", "pubdate": {"attribute_name": "公開日", "attribute_value": "2009-07-06"}, "publish_date": "2009-07-06", "publish_status": "0", "recid": "19863", "relation": {}, "relation_version_is_last": true, "title": ["Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations"], "weko_shared_id": -1}
Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations
http://hdl.handle.net/10098/2103
http://hdl.handle.net/10098/21036a879772-5827-4fa1-96f8-b75e3a2f4b3d
名前 / ファイル | ライセンス | アクション |
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clean_version_muraoka_JMRI.pdf (790.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2009-07-06 | |||||
タイトル | ||||||
タイトル | Apparent Diffusion Coefficient in Pancreatic Cancer: Characterization and Histopathological Correlations | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pancreatic cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | diffusion-weighted imaging | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | apparent diffusion coefficient | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | histopathological correlations | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
MURAOKA, Noriaki
× MURAOKA, Noriaki× UEMATSU, Hidemasa× KIMURA, Hirohiko× IMAMURA, Yoshiaki× FUJIWARA, Yasuhiro× MURAKAMI, Makoto× YAMAGUCHI, Akio× ITOH, Harumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To clarify the components primarily responsible for diffusion abnormalities in pancreatic cancerous tissue. Materials and Methods: Subjects comprised 10 patients with surgically confirmed pancreatic cancer. Diffusion-weighted (DW) echo-planar imaging (b value=0, 500 s/mm^2) was employed to calculate ADC. ADC values of cancer and non-cancerous tissue were calculated. Furthermore, ADC values of the cancer were compared with histopathological results. Results: Mean (±standard deviation) ADC value was significantly lower for tumor (1.27±0.52 ×10^<-3> mm^2/s) than for non-cancerous tissue (1.90±0.41×10^<-3> mm^2/s, P<0.05). Histopathological examination showed similar proportions of fibrotic area, cellular component, necrosis and mucin in each case. Regarding the density of fibrosis in cancer, 3 cases were classified to the loose fibrosis group, and the remaining 7 cases were classified to the dense fibrosis group. Mean ADC value was significantly higher in the loose fibrosis group (1.88±0.39×10^<-3> mm^2/s) than in the dense fibrosis group (1.01±0.29×10^<-3> mm^2/s, P<0.05). In quantitative analysis, ADC correlated well with proportion of collagenous fibers (r=-0.87, P<0.05). Conclusion: Collagenous fibers may be responsible for diffusion abnormalities in pancreatic cancer. | |||||
書誌情報 |
JOURNAL OF MAGNETIC RESONANCE IMAGING 巻 27, 号 6, p. 1302-1308, 発行日 2008-06 |
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出版者 | ||||||
出版者 | JOHN WILEY & SONS INC | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 10531807 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00006090 |