| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2011-12-06 |
| タイトル |
|
|
タイトル |
Pitavastatin Decreases Tau levels Via the Inactivation of Rho/ROCK |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Statin |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Pleiotrophic effects |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Tau |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Neuronal cellular model |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Small G protein |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Rho/ROCK |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 著者 |
HAMANO, Tadanori
YEN, Shu-Hui
GENDRON, Tania
KO, Li-wen
KURIYAMA, Masaru
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Epidemiological studies have shown that long-term treatment with statins decreases the risk of developing Alzheimer's disease. Statins have pleiotropic effects by lowering the concentration of isoprenoid intermediates. Although several studies have shown that statins may reduce amyloid beta protein levels, there have been few reports on the interaction between statins and tau. We report here that pitavastatin reduces total and phosphorylated tau levels in a cellular model of tauopathy, and in primary neuronal cultures. The decrease caused by pitavastatin is reversed by the addition of mevalonate, or geranylgeranyl pyrophosphate. The maturation of small G proteins, including RhoA was disrupted by pitavastatin, as was the activity of glycogen synthase kinase 3β (GSK3β), a major tau kinase. Toxin A, inhibitor of glycosylation of small G proteins, and Rho kinase (ROCK) inhibitor decreased phosphorylated tau levels. Rho kinase inhibitor also inactivated glycogen synthase kinase 3β. Although the mechanisms responsible for the reduction in tau protein by pitavastatin require further examination, this report sheds light on possible therapeutic approaches to tauopathy. |
| 書誌情報 |
Neurobiology of Aging
巻 33,
発行日 2011-11
|
| 出版者 |
|
|
出版者 |
ELSEVIER |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1974580 |
| 書誌レコードID |
|
|
|
識別子タイプ |
NCID |
|
|
関連識別子 |
TD00006164 |
| 著者版フラグ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
neurobiology_of_aging_revised11.pdf (351.9 kB)
