| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2008-12-09 |
| タイトル |
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|
タイトル |
Improvement of bladder storage function by α1-blocker depends on the suppression of C-fiber afferent activity in rats |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
C-fiber |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
α1-blockers |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
detrusor overactivity |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
cerebral infarction |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
rat |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 著者 |
YOKOYAMA, Osamu
YUSUP, Anwar
OYAMA, Nobuyuki
AOKI, Yoshitaka
TANASE, Kazuya
MATSUTA, Yosuke
MIWA, Yoshiji
AKINO, Hironobu
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Aims α1-blockers improve voiding symptoms through the reduction of prostatic and urethral smooth muscle tone; however, the underlying mechanism of improvement of storage symptoms is not known. Using a rat model of detrusor overactivity caused by cerebral infarction (CI), we undertook the present study to determine whether the effect of an 1-blocker, naftopidil, is dependent on the suppression of C-fiber afferents. Methods To induce desensitization of C-fiber bladder afferents, we injected resiniferatoxin (0.3 mg/kg, RTX) sub-cutaneously to female Sprague-Dawley rats 2 days prior to left middle cerebral artery occlusion (MCAO) (RTX-CI rats). As controls we used rats without RTX treatment (CI rats). MCAO and insertion of a polyethylene catheter through the bladder dome were performed under halothane anesthesia. We investigated the effects on cystometrography (CMG) of intravenous (i.v.), intracerebroventricular (i.c.v.), or intrathecal (i.t.) administration of naftopidil in conscious CI rats. Results Bladder capacity (BC) was markedly reduced after MCAO in both RTX-CI and CI rats. I.v. administration of naftopidil significantly increased BC in CI rats without an increase in residual volume, but it had no effects on BC in RTX-CI rats. I.t. administration of naftopidil significantly increased BC in CI but not in RTX-CI rats. Conclusions These results suggest that naftopidil has an inhibitory effect on C-fiber afferents in the lumbosacral spinal cord, improving BC during the storage phase. |
| 書誌情報 |
Neurourology and urodynamics
巻 25,
号 5,
p. 461-467,
発行日 2006
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| 出版者 |
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出版者 |
John Wiley & Sons |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
7332467 |
| 書誌レコードID |
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|
識別子タイプ |
NCID |
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|
関連識別子 |
TD00006312 |
NeuroUrolYokoyama_O.pdf (64.6 kB)
