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METHODS: Eighteen patients (mean age +/- SD, 61 +/- 16 y) with atherothrombotic large-cerebral-artery disease were studied for the measurement of hemodynamic parameters using the 15O-gas steady-state method with inhalation of 15O2, C15O2, and C15O. All patients also underwent H2(15)O PET with the bolus injection method. Count-based ratio images of 15O2/C15O2 and (15)O2/H2(15)O were calculated, and asymmetry indices (AIs) were obtained (cbOEF(SS)-AI and cbOEF(BO)-AI, respectively) using regions of interest drawn bilaterally on the cerebral cortices. These AIs were compared with the AIs of absolute OEF (qOEF-AI) and with those after cerebral blood volume (CBV) correction. A contribution factor for this correction was defined as a variable alpha, and the effect of the correction was evaluated. RESULTS: cbOEF(SS)-AI underestimated qOEF-AI significantly, especially with a greater AI (P \u003c 0.05). cbOEF(BO)-AI linearly correlated well with qOEF-AI. CBV correction improved the slopes of regression lines between qOEF-AI and cbOEF(SS)-AI, and the optimal alpha was defined as 0.5. On the other hand, cbOEF(BO)-AI fairly estimated qOEF-AI without CBV correction. Correlation between qOEF-AI and cbOEF(BO)-AI was adversely affected, and the mean bias was increased, with a greater alpha. CONCLUSION: cbOEF(BO)-AI can fairly estimate the AI of OEF without CBV correction, whereas cbOEF(SS)-AI might require CBV correction for better estimation. The examination time and stress to patients would be reduced with the count-based method because it is noninvasive.", "subitem_description_type": "Abstract"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Society of Nuclear Medicine"}]}, "item_10001_relation_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "TD00006264", "subitem_relation_type_select": "NCID"}}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1615505", "subitem_source_identifier_type": "ISSN"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_b1a7d7d4d402bcce", "subitem_version_type": "AO"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "KOBAYASHI, Masato"}], "nameIdentifiers": [{"nameIdentifier": "58981", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "OKAZAWA, Hidehiko"}], "nameIdentifiers": [{"nameIdentifier": "58982", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "TSUCHIDA, Tatsuro"}], "nameIdentifiers": [{"nameIdentifier": "58983", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "KAWAI, Keiichi"}], "nameIdentifiers": [{"nameIdentifier": "58984", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "FUJIBAYASHI, Yasuhisa"}], "nameIdentifiers": [{"nameIdentifier": "58985", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "YONEKURA, Yoshiharu"}], "nameIdentifiers": [{"nameIdentifier": "58986", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-08-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "Okazawa_Diagn.pdf", "filesize": [{"value": "257.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 257300.0, "url": {"label": "Okazawa_Diagn.pdf", "url": "https://u-fukui.repo.nii.ac.jp/record/20438/files/Okazawa_Diagn.pdf"}, "version_id": "8ab5a180-65fc-4b05-a158-90506f787cd0"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "oxygen extraction fraction", "subitem_subject_scheme": "Other"}, {"subitem_subject": "misery perfusion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "misery perfusion", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gas PET study", "subitem_subject_scheme": "Other"}, {"subitem_subject": "noninvasive method", "subitem_subject_scheme": "Other"}, {"subitem_subject": "cerebrovascular disease", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "other", "resourceuri": "http://purl.org/coar/resource_type/c_1843"}]}, "item_title": "Diagnosis of misery perfusion using noninvasive 15O-gas PET.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Diagnosis of misery perfusion using noninvasive 15O-gas PET."}]}, "item_type_id": "10001", "owner": "1", "path": ["2393"], "permalink_uri": "http://hdl.handle.net/10098/1196", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-11-30"}, "publish_date": "2007-11-30", "publish_status": "0", "recid": "20438", "relation": {}, "relation_version_is_last": true, "title": ["Diagnosis of misery perfusion using noninvasive 15O-gas PET."], "weko_shared_id": -1}
Diagnosis of misery perfusion using noninvasive 15O-gas PET.
http://hdl.handle.net/10098/1196
http://hdl.handle.net/10098/11961a300362-e9ff-478c-8c26-333cba0b6abb
名前 / ファイル | ライセンス | アクション |
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Okazawa_Diagn.pdf (257.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-11-30 | |||||
タイトル | ||||||
タイトル | Diagnosis of misery perfusion using noninvasive 15O-gas PET. | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | oxygen extraction fraction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | misery perfusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | misery perfusion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | gas PET study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | noninvasive method | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | cerebrovascular disease | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_1843 | |||||
資源タイプ | other | |||||
著者 |
KOBAYASHI, Masato
× KOBAYASHI, Masato× OKAZAWA, Hidehiko× TSUCHIDA, Tatsuro× KAWAI, Keiichi× FUJIBAYASHI, Yasuhisa× YONEKURA, Yoshiharu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To avoid arterial blood sampling and complicated analyses in 15O-gas PET studies, we evaluated a noninvasive technique using the count-based method for measuring asymmetric increases in oxygen extraction fraction (OEF) in cerebrovascular disease. METHODS: Eighteen patients (mean age +/- SD, 61 +/- 16 y) with atherothrombotic large-cerebral-artery disease were studied for the measurement of hemodynamic parameters using the 15O-gas steady-state method with inhalation of 15O2, C15O2, and C15O. All patients also underwent H2(15)O PET with the bolus injection method. Count-based ratio images of 15O2/C15O2 and (15)O2/H2(15)O were calculated, and asymmetry indices (AIs) were obtained (cbOEF(SS)-AI and cbOEF(BO)-AI, respectively) using regions of interest drawn bilaterally on the cerebral cortices. These AIs were compared with the AIs of absolute OEF (qOEF-AI) and with those after cerebral blood volume (CBV) correction. A contribution factor for this correction was defined as a variable alpha, and the effect of the correction was evaluated. RESULTS: cbOEF(SS)-AI underestimated qOEF-AI significantly, especially with a greater AI (P < 0.05). cbOEF(BO)-AI linearly correlated well with qOEF-AI. CBV correction improved the slopes of regression lines between qOEF-AI and cbOEF(SS)-AI, and the optimal alpha was defined as 0.5. On the other hand, cbOEF(BO)-AI fairly estimated qOEF-AI without CBV correction. Correlation between qOEF-AI and cbOEF(BO)-AI was adversely affected, and the mean bias was increased, with a greater alpha. CONCLUSION: cbOEF(BO)-AI can fairly estimate the AI of OEF without CBV correction, whereas cbOEF(SS)-AI might require CBV correction for better estimation. The examination time and stress to patients would be reduced with the count-based method because it is noninvasive. | |||||
書誌情報 |
Journal of Nuclear Medicine 巻 47, 号 10, p. 1581-1586, 発行日 2006-10 |
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出版者 | ||||||
出版者 | Society of Nuclear Medicine | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1615505 | |||||
書誌レコードID | ||||||
識別子タイプ | NCID | |||||
関連識別子 | TD00006264 | |||||
著者版フラグ | ||||||
出版タイプ | AO | |||||
出版タイプResource | http://purl.org/coar/version/c_b1a7d7d4d402bcce |