| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2007-11-16 |
| タイトル |
|
|
タイトル |
A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Plasma membrane |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Chlorpromazine |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Haloperidol |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Sulpiride |
| キーワード |
|
|
主題Scheme |
Other |
|
主題 |
Extrapyramidal side effects |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_1843 |
|
資源タイプ |
other |
| 著者 |
Murata, Tetsuhito
Maruoka, Nobuyuki
Omata, Naoto
Takashima, Yasuhiro
Fujibayashi, Yasuhisa
Yonekura, Yoshiharu
Wada, Yuji
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
We compared the potency of the interaction of three antipsychotic drugs, i.e., chlorpromazine (CPZ), haloperidol (HAL) and sulpiride (SUL), with the plasma membrane in the rat brain. CPZ loading ( 100 M) dose-dependently increased both membrane permeability (assessed as [18F]2-fluoro-2-deoxy-D-glucose-6-phosphate release from brain slices) and membrane fluidity (assessed as the reduction in the plasma membrane anisotropy of 1,6-diphenyl-1,3,5-hexatriene). On the other hand, a higher concentration of HAL (1 mM) was required to observe these effects. However, SUL failed to change membrane permeability and fluidity even at a high concentration (1 mM). These results indicated the following ranking of the potency to interact with the membrane: CPZ > HAL > SUL. The difference among antipsychotic drugs in the potency to interact with the plasma membrane as revealed in the present study may be partly responsible for the difference among the drugs in the probability of inducing extrapyramidal side effects such as parkinsonism and tardive dyskinesia. |
| 書誌情報 |
The international journal of neuropsychopharmacology
巻 10,
号 5,
p. 683-689,
発行日 2007-10
|
| 出版者 |
|
|
出版者 |
Cambridge University Press |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
14611457 |
| 書誌レコードID |
|
|
|
識別子タイプ |
NCID |
|
|
関連識別子 |
TD00006262 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1017/S1461145706007218 |
| 著者版フラグ |
|
|
出版タイプ |
AO |
|
出版タイプResource |
http://purl.org/coar/version/c_b1a7d7d4d402bcce |
Murata_comp.pdf (392.5 kB)
